Lara Croft is tasked by MI6 to find the mythological Pandora's Box, an object from ancient legends which supposedly contains one of the deadliest plagues on Earth, before evil Nobel Prize-winning scientist turned bioterrorist Jonathan Reiss can get his hands on it. Lara ventures to an underwater temple in search of a magical luminous orb, the key to finding Pandora's Box, but after securing it, it is promptly stolen by the villainous leader of a Chinese crime syndicate who in turn plans to sell the orb to Reiss. Lara must recover the box before evil mastermind Reiss uses it to construct a weapon of catastrophic capabilities.